1. Provide one more choice for doctors to formulate drugs.
2. Solve the needs of special groups to drink soup medicine, such as migrant workers, business people, going to work, going to school, traveling, and tourists.
3. Build a modern Chinese medicine pharmacy.
4. The hospital does not need to set up a decoction room.
5. Enhance the competitiveness of traditional Chinese medicine hospitals or traditional Chinese medicine departments, and increase the number of traditional Chinese medicine outpatient clinics.
6. Improve work efficiency and simplify management procedures. is item.
Although formula granules maintain the corresponding range and usage with decoction pieces in clinical application, in fact, they are no longer decoction pieces but a new dosage form. It has the advantages of stable quality, reliable curative effect, safety and convenience, and can no longer be regarded as equivalent to decoction pieces.
Product specifications refer to: **g of granules in each bag is equivalent to **g of Chinese medicine decoction pieces.
There is only one packaging specification based on the following considerations:
1. If a variety has 4 specifications of packaging equivalent to 1, 2, 5, and 10 grams of decoction pieces, then 500 varieties will require 2000 packaging specifications, which does not meet the actual conditions of production and clinical application.
2. Too small amount of packaging is not up to the current packaging technology.
3. Thousands of varieties with multiple specifications will cause great inconvenience to pharmacies, drug warehouses, and pricing systems, and are prone to errors. And increase production costs and increase the economic burden of patients.
4. From the perspective of syndrome differentiation and treatment in traditional Chinese medicine, the single-flavored medicine in small bags can meet the increase and decrease of the flavor of the medicine, but due to the fixed dosage of the package, the flexibility of increasing or decreasing the amount of the single-flavored medicine is limited, and can only be delivered in multiples of the packaging specifications.
Bring inconvenience to the doctor's medication habits. However, this method basically guarantees the prescription of medicines based on syndrome differentiation.
The packaging specifications are determined according to the daily dosage of each medicine for adults (referring to the daily dosage of the dried crude drug in the decoction for adults 1 day), and the dosage for adults is based on the "Chinese Pharmacopoeia", herbal works and contemporary traditional Chinese medicine clinical practice.
The amount is determined.
For general adult prescription, one sachet of each medicine is sufficient, and the amount can be increased under special circumstances, such as Buyang Huanwu Decoction and 3-6 packs of Astragalus.
Children under 5 years old usually take a quarter of the adult dosage; 5-9 years old should be halved for adults; 9-12 year olds should be used 2/3 of the adult dosage. It is a medicine for adults. After adding water to dissolve it, drink 1/4 or 1/2 first, cover the remaining part in the refrigerator, and heat it when drinking.
The key to mastering the dosage is to gradually become familiar with the "Specifications of Chinese Medicine Formula Granules".
How to prescribe:
After the doctor is familiar with the specifications of each bag, directly use the number of packages to prescribe. This method is not only easy for doctors to master, but also convenient for hospitals to calculate prices and distribute medicines.
Yinqiaosan --- 1 pack of Forsythia, 1 pack of honeysuckle, 1 pack of Platycodon, 1 pack of mint, 1 pack of light bamboo leaves, 1 pack of licorice, 1 pack of nepeta, 1 pack of light tempeh, 1 pack of burdock seeds.
Danggui Buxue Decoction --- 3 packs of Astragalus and 1 pack of Angelica. The gram can also be the unit of measurement, and the granules can be indicated.
Astragalus 30g and Angelica 10g.
1. Preparation method: tear each bag of the medicine prescribed by the doctor along the reserved incision, pour it into the same cup, moisten it with a small amount of boiling water, then pour 250 ml of boiling water, and stir until it dissolves. Let the medicinal solution cool or warm, and take it twice in the morning and evening.
When taking it at night, add some hot water to heat.
Matters needing attention:
(1) Be sure to use boiling water (90-100 degrees C.
(2) After adding water, stir for about 30 seconds to 1 minute until it is fully dissolved.
(3) There must be sufficient water.
(4) Some precious crude drugs are superfinely pulverized and used as medicine.
They cannot be dissolved and can be taken after shaking.
Some varieties of formula granules will not dissolve or partially dissolve when they are taken, or dissolve slowly.
There are two reasons for the above phenomenon:
(1) The granule itself is made of medicinal materials after micronization, which is similar to powder when it is taken, with insoluble and precipitation phenomena. Such as: Chuan Fritillaria, Gastrodia, Scorpion, Centipede, Agarwood, Ginseng, Panax notoginseng, etc.
(2) Some seed kernels and root products appear turbid or flocculate when being taken, especially when the liquid medicine is left cold. This is because some of the substances contained in this kind of medicine can be used in the liquid medicine at a higher temperature. It dissolves in the liquid and condenses in the lower temperature liquid medicine.
Such products include:
Plantago Seed, Cuscuta Seed, Pinellia pinellia and so on. The emergence of insoluble phenomenon is mainly caused by improper mixing method, such as low water temperature and insufficient stirring.
The "insoluble" that patients often report refers to this category.
The so-called "heating" phenomenon refers to the symptoms of dryness, discomfort or pain in the throat of some patients after taking Chinese medicine granules.
The reasons for this symptom are as follows:
(1) It is a physique of Yin deficiency and fire. After taking some warm drugs, it will become "incredible".
(2) In the production process of traditional Chinese medicine formula particles, spray drying and other material heating processes are required. According to Chinese medicine, the products after frying and baking are dry in nature, and very few people will "get angry" after taking them.
(3) In clinical practice, doctors should adjust the taste of the medicine according to the specific situation, and the phenomenon of getting angry will soon disappear.
This phenomenon is mainly reflected in the southern areas of Guangdong, Guangxi, and Hong Kong.
The appearance of aliases of traditional Chinese medicine has a long history in China, and regional names are a major source of aliases of traditional Chinese medicine.
Due to the vast territory of China, the same Chinese medicine can be distributed in different regions with different names. For example, the traditional Chinese medicine Aidi tea, which is called Aidicha, Aishancha, and Zijinniu in Hunan; Jiangsu, Jiangxi, and Fujian are called Pingdimu; Sichuan is also called Xiaodifeng; Jiangxi is also called Cinnamomum camphora and Dicha; Henan is called Poxie Beads. It can be seen that regional names occupies a large proportion of the aliases of Chinese medicine.
The Dictionary of Traditional Chinese Medicine compiled by Jiangsu New Medical College contains more than 23,000 aliases. In different regions, the name of the same Chinese medicine is different, and doctors often like to prescribe customary names, aliases, and trade names when prescribing. According to the strict management requirements of medicines, the names of doctors' prescriptions are partly irregular.
According to the "Technical Requirements for the Study of Quality Standards for Chinese Medicine Formula Granules" by the State Food and Drug Administration of China, the name of Chinese medicine prescription granules must adopt the names of Chinese herbal medicines in the "Chinese Pharmacopoeia" and the ministry-issued standard Chinese medicinal materials.
Therefore, the names of some formula granules are different from those used in local prescriptions.
The Traditional Chinese Medicine Formula Granules are processed and produced according to the characteristics of the traditional Chinese medicine decoction pieces, maintaining the medicinal and medicinal taste of the traditional Chinese medicine decoction pieces, and replacing the decoction pieces for clinical formula use. It is mainly used for internal medicine, with less external medicine.
Generally speaking, most external medicines cannot be used internally, and internal medicines can be selected for external use according to specific conditions. Traditional Chinese medicine formula granules are manufactured in a clean environment in a clean area of 100,000 grades.
The hygienic standards are in full compliance with the oral preparation standards of the Chinese Pharmacopoeia.
Enema, external application and external washing can be applied.
1. Most of the two have no difference in appearance and taste.
2. Whether or not the chemical composition and efficacy of the two forms of "single decoction" and "mixed decoction" are different or how much difference is there, our current research only has 20 classic prescriptions such as "Qingwei San". It is still difficult to make a comprehensive conclusion, but we can understand this problem from the following aspects:
2.1 Traditional Chinese medicine has a variety of dosage forms such as ointment, pill, pill, powder, decoction, etc. since ancient times, among which pill, pill and powder are not the product of co-decocting of Traditional Chinese Medicine.
There are 208 representative and commonly used basic prescriptions included in the textbook of "Prescriptions" in medical colleges and universities; 148 are derived prescriptions and supplementary prescriptions with similar composition or efficacy, including 136 prescriptions that are used as pills and powders.
Accounted for 38.2%, such as Yinqiao powder, Liuwei Dihuang Wan, Pingwei powder, Sini powder, Yupingfeng powder and so on. Pills and powders are not used together with decoction pieces, and the efficacy of these prescriptions can also withstand the test of history. They are imitated as classic prescriptions and are incorporated into teaching books. It is just that modern doctors use these pills and powders to dialect the basic prescriptions.
The composition of the decoction application only.
2.2 According to some research reports in China and abroad, when medicines are mixed and decocted together, some medicine components will interact with each other, but most of them are the interaction of acid and alkaline components.
However, there is no clear report on the impact of the interaction of chemical substances between the drugs on the clinical efficacy. A large number of studies have shown that Coptis contains berberine. When it is decocted with several major acid-containing medicinal materials, acid-base precipitates will dissolve in the small intestinal juice, and the acid and alkali components can be restored.
There are also some reports that the chemical composition analysis and pharmacological tests of the compound "single decoction" and "mixed decoction" liquids show no significant difference.
2.3 The chemical change between the compatible components of Chinese medicine is a complex process. The organic chemical reaction requires certain temperature, pressure, time, catalyst and other conditions to occur.
Therefore, what chemical reactions can occur under pure water decocting conditions It is difficult to determine.
2.4 Our company has carried out research work in this area in conjunction with relevant units, and selected ten classic (experimental) recipes with definite curative effects, including Qianghuo Shengshi Decoction, Qingwei San, Guipi Decoction, and Suanzaoren Decoction, and carried out separate decoction and combined decoction.
Comparative study of chemical components, comparative study of pharmacological effects, comparative study of clinical efficacy.
The results of the study showed that there was no significant difference in the chemical composition and clinical efficacy of the two decoctions.
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